A New β-Lapachone Derivative from Distictella elongata (Vahl) Urb
نویسندگان
چکیده
O presente trabalho descreve a elucidação estrutural de uma nova β-lapachona tipo naftoquinona, isolada a partir das raízes de Distictella elongata. A nova substância, apresentando fórmula molecular C 16 H 16 O 6 , foi identificada como sendo 4,7-diidróxi-10-metóxi-2,2-dimetil3,4-diidro-2H-benzo[h]cromeno-5,6-diona, de acordo com os dados obtidos por meio de análises espectrométricas. A elucidação estrutural foi realizada utilizando-se as técnicas espectrométricas [HRESIMS, 1D RMN (H e C) e 2D RMN (g-DQF-COSY, g-HMQC e g-HMBC]. O extrato clorofórmico das raízes de D. elongata demonstrou significante inibição no crescimento de células do tipo SK-MEL (melanoma) e SK-OV-3 (carcinoma de ovário), com valores de IC 50 de 40 μg mL e 56 μg mL, respectivamente. Entretanto, a naftoquinona não foi responsável pela atividade citotóxica exibida pelo extrato.
منابع مشابه
Chemical constituents of Distictella elongata (Vahl) Urb. (Bignoniaceae).
Pectolinarin, a flavone heteroside, was isolated from Distictella elongata (Vahl) Urb. leaves ethanol extract, along with a mixture of ursolic, pomolic and oleanolic acids, besides β-sitosterol. Their structures were established on the basis of spectral analysis (1H and 13C NMR, 1D and 2D) and they were compared with literature. This is the first report on the occurrence of this flavonoid in a ...
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